Keywords: Other Neurodegeneration, Brain Connectivity, cerebellum; fMRI (resting state); cerebellar network
Motivation: Functional network changes of the cerebellum in patients with spinocerebellar ataxia type 3 (SCA3) have been scarcely assessed.
Goal(s): To investigate the functional topological characteristics of cerebellar network connectivity and modular changes in SCA3.
Approach: Graph theoretical method were used in this study to provide quantified topological organization and modular analyses of functional cerebellar networks.
Results: The small-world organization of the cerebellum was spared in patients with SCA3. Compared with healthy controls, increased inter-modular connectivity between frontoparietal network and dorsal somatomotor network and decreased intra-modular connectivity in cerebellar default mode network were shown in SCA3 patients.
Impact: This study displays the functional cerebellar topological network in SCA3. The abnormalities of cerebellar modular connectivity support SCA3 as a network disorder, which further enhance the interpretation of SCA3 from the perspective of neuroimaging.
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