Abstract #4380

Iron deposition of basal ganglia on 7 Tesla MRI for diagnosis of early-stage Parkinson’s disease

Jianing Jin^1,2, Dongning Su¹, Zhe Zhang³, Jing Jing³, Yuan Li⁴, and Tao Feng¹

¹Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²China National Clinical Research Center for Neurological Diseases, Beijing, China, ³Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴MR Research Collaboration Team, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Early diagnosis of Parkinson's disease (PD) remains challenging.

Goal(s): Aimed to identify new imaging features in the basal ganglia of PD by 7T iron-sensitive MRI, and to investigate the diagnostic performance of the new imaging features in distinguishing early-stage PD patients from healthy subjects.

Approach: 129 participants were prospectively recruited between May 2021 and September 2023. All participants were scanned at Tiantan Neuroimaging Center using 7-Tesla MRI. Two neuroradiologist separately evaluated the visual rating scale of iron deposition signs in basal ganglia.

Results: The newly developed basal ganglia sign scoring scale showed high sensitivity and excellent specificity for diagnosis of early-stage PD.

Impact: The distribution characteristics of iron deposition in basal ganglia might be a promising marker of the diagnosis of early-stage PD.

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