Keywords: Parkinson's Disease, Diffusion Tensor Imaging
Motivation: The genetic variant rs9638616, is associated with Parkinson’s Disease (PD) risk in Asian populations.
Goal(s): To provide insight into the neural correlates of rs9638616 in Asian PD, to inform risk models and idiopathic PD aetiology.
Approach: Using imaging and genotyping data from 116 early-PD patients and 57 controls of Chinese ethnicity, we performed voxelwise analyses to assess rs9638616 T-allele association with brain microstructure, morphology and function.
Results: Our results suggest that rs9638616 may confer PD risk in Asian cohorts via lower white matter fractional anisotropy and reduced supplementary motor area functional connectivity.
Impact: In an imaging-genetics analysis, the Asian PD risk variant rs9638616 was associated with altered brain structure/function. This rationalises rs9638616’s role in PD risk, and may be useful in improving PD stratification and risk modeling.
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