Abstract #4388

Dorsal nigral hyperintensity abnormality in 7T MRI is a biomarker for diagnosis of Parkinson’s disease and atypical parkinsonisms

Dongning Su¹, Zhijin Zhang¹, Zhe Zhang², Rui Yan¹, Wanlin Zhu², Ning Wei², Yue Suo², Xinyao Liu², Huiqing Zhao¹, Zhan Wang¹, Huizi Ma¹, Junhong Zhou³, Joyce S. T. Lam⁴, Yuan Li⁵, Tao Wu¹, Jing Jing², and Tao Feng¹

¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States, ⁴Pacific Parkinson’s Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada, ⁵MR Research Collaboration Team, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, 7T MRI; dorsal nigral hyperintensity

Motivation: The dorsal nigral hyperintensity (DNH) abnormality is a characteristic feature of PD and 7T MRI has proved useful for its visualization.

Goal(s): To investigate the diagnostic efficiency of DNH abnormality at different stages of PD and in atypical parkinsonisms using 7T MRI.

Approach: PD, RBD, MSA-P, MSA-C, and PSP patients and controls underwent 7T T2* with DNH abnormality assessed for diagnostic performance. R2* mapping and principal component analysis were performed in substantia nigra.

Results: MSA-C and RBD demonstrated higher preservation rate of DNH than PD, MSA-P, and PSP. DNH scoring criteria proved an optimal diagnostic method of PD, RBD, MSA-P, MSA-C, and PSP.

Impact: MSA-C and RBD patients had higher dorsal nigral hyperintensity (DNH) preservation rate compared with PD, MSA-P, and PSP. The DNH scoring criteria proved an optimal diagnostic method of PD, RBD, MSA-P, MSA-C, and PSP.

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