Keywords: Gray Matter, Neuro, cognitive impairment
Motivation: Hemodialysis (HD) leads to cognitive impairment; however, the pathophysiology of maintenance HD remains unclear.
Goal(s): This study aimed to investigate the longitudinal alterations in gray matter volume (GMV), cerebral blood flow (CBF) and functional connectivity (FC) in patients on follow-up HD compared with baseline HD.
Approach: All participants underwent high-resolution T1-weighted imaging, arterial spin labeling, and functional MR imaging to measure GMV, CBF, and FC.
Results: The right and left medial superior frontal gyrus (SFGmed.L) exhibited significantly lower GMV and CBF in patients on follow-up HD compared with baseline HD and lower FC between the SFGmed.L and left middle temporal gyrus.
Impact: Our findings provide unique insights into the pathological mechanisms of patients on maintenance HD with cognitive impairment.
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