Keywords: Gray Matter, fMRI (resting state), chronic prostatitis/chronic pelvic pain syndrome
Motivation: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is mainly characterized by persistent pain and discomfort in the pelvic region, which seriously affects the young and middle-aged men in China.
Goal(s): Further exploration of the central mechanisms is essential to gain a deeper understanding of this chronic pain condition.
Approach: This study, based on multimodal MRI and combined with clinical questionnaires and scales, adopts a cross-sectional design to systematically analyze the changes in gray matter and resting-state functional connectivity abnormalities.
Results: The structure and function of the striatum are altered in CP/CPPS patients.
Impact: The study results provide objective evidence of cerebral abnormalities to further understand the central pathophysiological mechanisms of CP/CPPS. They also offer valuable neuroimaging-based insights for future clinical advancements in precise diagnosis and treatment of CP/CPPS.
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