Keywords: fMRI Analysis, Pediatric, Autism
Motivation: The combination of fecal microbiota transplantation (FMT) and resting-state fMRI (rs-fMRI) can provide a new imaging perspective for understanding the neural mechanism of gut microbiota in ASD.
Goal(s): This study is to evaluate the functional alterations and investigate the potential mechanisms of FMT treatment in ASD.
Approach: Amplitude of low-frequency fluctuation (ALFF) and Regional Homogeneity (ReHo) based on rs-fMRI are useful methods to characterize brain function and activity.
Results: After FMT treatments, the higher ALFF and ReHo values in the left angular gyrus and bilateral lingual gyrus, which could become the underlying mechanism of improvements.
Impact: FMT can improve the symptoms of ASD and influence the brain functional activity. Combining FMT and MRI can provide a new imaging perspective for understanding the neural mechanism and assist clinical follow-up of ASD.
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