Keywords: fMRI Analysis, Alzheimer's Disease, Parkinson's Disease fMRI
Motivation: The pathogenesis of cognitive dysfunction may be different, particularly in terms of macroscopic manifestations within neural transmission pathways, which still require further exploration.
Goal(s): The aim of this study was to quantify changes in fMRI intra and inter-network connectivity in AD-MCI and PD-MCI using independent component analysis (ICA).
Approach: Nine RSNs were identified in 33 AD-MCI, 55 PD-MCI and 34 HCs using ICA method, and further their intra-and inter-network FC were compared in three groups.
Results: The results showed that the brain network changes in AD-MCI patients and PD-MCI patients were mainly concentrated in different brain network.
Impact: By investigating the pathways and compensatory mechanisms underlying cognitive dysfunction arising from different etiologies, we aim to explore potential imaging-based diagnostic approaches and therapeutic strategies for clinical treatment strategy, which is enhancing the prognosis and quality of life for patients.
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