Abstract #4416

Altered task-residual effective connectivity of motor and memory network in transient ischemic attack

Truc Chu^1,2, Seonjin Lee^1,2, Il-Young Jung³, Youngkyu Song⁴, Hyun Ah Kim⁵, Anh Nguyen^1,2, Jong Wook Shin⁶, and Sungho Tak^1,2

¹Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Cheongju, Korea, Republic of, ²Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea, Republic of, ³Department of Rehabilitation Medicine, Chungnam National University Sejong Hospital, Sejong, Korea, Republic of, ⁴Bio-Chemical Analysis Team, Korea Basic Science Institute, Cheongju, Korea, Republic of, ⁵Department of Rehabilitation Medicine, Chungnam National University Hospital, Daejeon, Korea, Republic of, ⁶Department of Neurology, Chungnam National University Sejong Hospital, Sejong, Korea, Republic of

Synopsis

Keywords: Functional Connectivity, fMRI, Effective Connectivity

Motivation: Little is known about underlying brain mechanisms that contribute to heightened risk of stroke and impairments in cognitive and motor functions of patients with transient ischemic attack (TIA).

Goal(s): Our aim was to investigate abnormal effective connectivity in TIA during motor and working memory tasks.

Approach: Spectral dynamic causal modelling with 7T fMRI was used to estimate the task-residual effective connectivity elicited during fist-closing and n-back tasks.

Results: Patients with TIA showed increased effective connectivity toward the ipsilateral M1 and reduced connectivity to the SMA and PMC durn motor task, as well as increased connectivity among the PAR and CC during n-back tasks.

Impact: The findings of aberrant task-residual effective connectivity within the motor and working memory networks in patients with TIA indicate potential decreased neural efficiency and disrupted control of motor and working memory functions, contributing to the physiological alterations in these individuals.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.