Keywords: CEST / APT / NOE, CEST & MT
Motivation: The histological grade of rectal cancer has a considerable involvement in treatment strategies and prognosis in relevant patients.
Goal(s): To evaluate the utility of glucose chemical exchange saturation transfer (glucoCEST) MRI with non-contrast injection in predicting the histological grade of rectal cancer.
Approach: This prospective analysis included 60 patients with rectal cancer who underwent pelvic glucoCEST, APTWI, and DWI.
Results: Elevated MTRasym (1.2 ppm), MTRasym (3.5 ppm) values and lower ADC values were observed in the high-grade group compared with low-grade cases (all P < 0.01). The AUCs of MTRasym (1.2 ppm), MTRasym (3.5 ppm), and ADC were 0.792, 0.839, and 0.855, respectively.
Impact: These preliminary data demonstrate that glucoCEST MRI without contrast injection has the potential to provide a non-invasive assessment of histological grade in rectal cancer and add value to current tools used for the differentiation between high- and low-grade rectal cancer.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords