Keywords: CEST / APT / NOE, CEST & MT
Motivation: CEST suffers from saturation inhomogeneities, especially at ultra-high fields. Universal pulses enable calibration-free mitigation of these inhomogeneities. However, it is not obvious how well PUSHUP translates to different scanners.
Goal(s): The goal of this work is to evaluate the feasibility of PUSHUP-CEST to obtain homogeneous whole-brain, high-resolution CEST maps in multi-center studies.
Approach: PUSHUP was calculated using a joined database of three sites. Multiple CEST measurements were performed at each site. The mean CEST amplitudes were compared in four brain segments.
Results: The resulting CEST maps were homogeneous and without major image artifacts. No significant bias could be found between sites.
Impact: PUSHUP allows for high-resolution, whole-brain CEST mapping at 7T. The feasibility of PUSHUP saturation for multi-center CEST studies and the use of joined databases for pulse calculation are demonstrated. No site-bias is found. This fosters CEST mapping in large-scale studies.
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