Abstract #4461

Whole-cerebrum guanidino and amide CEST mapping at 3T by 3D EPI GRE and 3D stack-of-spiral GRE acquisitions

Kexin Wang^1,2, Licheng Ju², Yulu Song³, Kevin Xie², Claire Liu², Anna Li², Dan Zhu^2,3, Feng Xu^2,3, Guanshu Liu^2,3, Hye-Young Heo^2,3, Nirbhay Narayan Yadav^2,3, Georg Oeltzschner^2,3, Richard A.E. Edden^2,3, Qin Qin^2,3, Lindsay Blair⁴, David Olayinka Kamson⁴, and Jiadi Xu²

¹Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: We are driven by the critical need to efficiently map guanidino and amide CEST in the human brain at 3T, enabling the investigation of brain creatine and protein while adhering to clinical scan time constraints.

Goal(s): Our aim is to validate the efficacy of 3D EPI GRE and 3D stack-of-spiral (3DSOS) GRE techniques for rapid guanidino and amide CEST mapping at 3T.

Approach: We optimized saturation parameters, conducted a comparative analysis of SNR and reproducibility, and demonstrated 3DSOS in a low-grade glioma patient.

Results: Both techniques yielded similar CEST signal intensities, with 3DSOS showing superior reproducibility.

Impact: While 3DEPI and 3DSOS yielded similar signal intensity in whole-cerebrum guanidino and amide CEST mappings at 3T, the latter is recommended for clinical application with its enhanced reproducibility and showed an increase of guanidino CEST in the tumor.

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