Abstract #4462

Periodically Rotated Spiral Sampling (PRSS) and Multi-offset Transformer Reconstruction (MoTR) for CEST MRI

Huabing LIU^1,2,3, Yang LIU¹, Abdul-Mojeed Olabisi ILYAS², Jianpan HUANG⁴, Dinggang SHEN^2,3,5,6, and Kannie W.Y. CHAN^1,2,7

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China, ³School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China, ⁴Department of Diagnostic Radiology, University of Hong Kong, Hong Kong, China, ⁵Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China, ⁶Shanghai Clinical Research and Trial Center, Shanghai, China, ⁷Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, United States

Synopsis

Keywords: Image Reconstruction, CEST & MT, Spiral Sampling

Motivation: CEST MRI is often limited in its application due to its time-consuming nature. Also, multiple saturation frequency offsets are required to accurately measure CEST effects.

Goal(s): Accelerate CEST imaging by undersampling k-space of each frequency offset below Nyquist rate.

Approach: Periodically rotated spiral sampling (PRSS) is proposed to make adjacent offsets capture different k-space subregions. Besides, a multi-offset transformer reconstruction (MoTR) network is further presented to fuse complementary information from multiple offsets.

Results: Compared to fully-sampled images, reconstructed images using our method can achieve an average SSIM/MAE of 0.9899/0.0032, resulting a coefficient R value of 0.93/0.95 in terms of CEST signals at -3.5ppm/+3.5ppm.

Impact: Our method can realize 4× acceleration of CEST imaging without sacrificing down-stream CEST analysis performance. Besides, our method has the potential to work on MRI scanner for CEST acceleration, which can further expand the application of CEST MRI.

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