Abstract #4470

Brain Temperature Mapping Based on Chemical Exchange Saturation Transfer of Creatine at 5.0T

Siqi Cai^1,2, Chongxue Bie¹, Yang Zhou¹, Chao Zou¹, Xi Xu^1,2, Chunxiang Jiang¹, and Lijuan Zhang^1,2

¹Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²University of Chinese Academy of Science, Beijing, China

Synopsis

Keywords: CEST / APT / NOE, Thermometry

Motivation: High-resolution brain thermometry remains challenging.

Goal(s): To estimate the feasibility of creatine chemical exchange saturation transfer (CrCEST) imaging for brain thermometry.

Approach: The CrCEST imaging of creatine phantom and swine brain was conducted at various temperatures on a 5.0T MR scanner (UIH Jupiter). The relationship between the apparent offset of CrCEST and the temperature was estimated with regression analysis, based on which the temperature maps were generated.

Results: Strong linear relationships between temperature and the apparent CrCEST offset were identified for both the creatine phantom (0.005ppm/^oC) and the ex vivo swine brain (0.008ppm/^oC) experiments.

Impact: The linear relationship between the apparent CrCEST offset and temperature confirmed the feasibility of CrCEST for high-resolution brain thermometry.

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