Abstract #4479

Evaluating the effectiveness of distortion self-correction for CEST-EPI

Jianpan Huang^1,2, Se Weon Park^2,3, and Kannie W. Y. Chan^2,3,4,5,6

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong, China, ³Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, China, ⁶City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

Synopsis

Keywords: Data Processing, CEST & MT, EPI

Motivation: EPI-based CEST (CEST-EPI) is fast but suffers from image distortion caused by field susceptibility.

Goal(s): We aimed to evaluate the effectiveness of using the field map generated by the Z-spectra to achieve the distortion self-correction (DISC) for single-shot CEST-EPI without additional acquisition of a field map.

Approach: The effectiveness of DISC strategy was demonstrated in CEST-EPI experiments of a creatine phantom and in vivo mice. CEST-RARE was used as a reference.

Results: Without acquiring an additional field map, DISC retrospectively and effectively corrected geometric distortion in CEST-EPI, leading to improved SSIM and spatial CEST contrasts.

Impact: We evaluated the effectiveness of using the field map generated by the Z-spectra to achieve the distortion self-correction for single-shot CEST-EPI. Results showed that DISC retrospectively and effectively corrected geometric distortion in CEST-EPI without acquiring an additional field map.

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