Abstract #4481

Motion-induced B1+-changes in dynamic glucose enhanced (DGE) MRI and how to remedy them.

Patrick M. Lehmann¹, Emil Ljungberg^1,2, Karin Markenroth Bloch³, Nirbhay N. Yadav^4,5, Ronnie Wirestam¹, Pia C. Sundgren^3,6,7, Peter C. van Zijl^4,5, and Linda Knutsson^1,5,8

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Neuroimaging, King’s College London, London, United Kingdom, ³Lund University Bioimaging Centre, Lund University, Lund, Sweden, ⁴Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁶Department of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, ⁷Department of Radiology, Lund University, Lund, Sweden, ⁸Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: CEST / APT / NOE, Brain, Motion Correction

Motivation: Motion-induced B1+-changes at the voxel level result in erroneous dynamic glucose enhanced (DGE) MRI effects.

Goal(s): To investigate effects of motion-induced B1+-changes on DGE MRI and to address removing them.

Approach: A volunteer changed head positions, and voxel-based B1+ was measured pre- and post-motion. Z-spectra with and without D-glucose infusion were simulated, with and without the measured B1+-changes.

Results: Slight motion-induced B1+-alterations lead to pseudo-CEST effects comparable to DGE effects. These can be removed by acquiring a full Z-spectrum and using the asymmetry of the glucoCEST signal relative to the water frequency to assess the DGE signal changes.

Impact: Motion-induced B1+-changes affect DGE signals, thus causing pseudo-CEST effects that complicate clinical interpretation. These effects can be overcome by acquiring a full Z-spectrum and exploiting the asymmetry of the glucoCEST signal changes relative to the water frequency.

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