Keywords: CEST / APT / NOE, CEST & MT, Exchange rate quantification
Motivation: Fitting CEST-MRI spectra using numerical methods is currently a time-consuming process, involving various approximations for initial parameters to expedite the process.
Goal(s): We aimed to derive the exact analytical expression for CEST Z-spectra of a two-pool exchange system.
Approach: We directly solved the Bloch-McConnell differential equations in matrix form for a two-pool exchange system to determine water magnetization under a steady-state saturation over the entire Z-spectrum.
Results: The analytical solution accurately reproduces spectra obtained through numerical methods. It allows fitting for physical parameters of the exchange system (like the exchange rate) as demonstrated by fitting simulated CEST spectra.
Impact: The analytical solution significantly reduces fitting time compared to the numerical methods used for fitting CEST Z-spectra. This solution has been demonstrated for the determination of physical parameters in the exchange system with fewer assumptions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords