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Abstract #4546

Amide Proton Transfer Imaging Has added Value for Predicting Extraprostatic Extension in Prostate Cancer Patients

Xiaoyan Qin1, Ronghua Mu1, Kan Deng2, Wei Zheng1, Yang Peng1, Bingqin Huang1, Zhiwei Shen3, and Xiqi Zhu1
1Department of Radiology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China, 2Philips Healthcare, Guangzhou, China, 3Philips Healthcare, Beijing, China

Synopsis

Keywords: Quantitative Imaging, Cancer

Motivation: Multi-parametric MRI is the most favorable imaging technique for local staging of PCa. Creating a combined model using these parameters would be desirable to improve the assessment of EPE.

Goal(s): To verify the diagnostic efficiency of tumor size, LCC, ADC, APT, and their combined models for predicting EPE.

Approach: The difference of tumor size, LCC, ADC and APT value between groups were compared. The ROC analysis was used for EPE prediction.

Results: APT, ADC, tumor size and the LCC were independent predictors of EPE. The AUC of model III (APT +ADC+LCC+tumor size) were 0.869.

Impact: These findings hold crucial clinical significance in the selection of appropriate therapeutic strategies for clinical cases of prostate cancer.

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