Abstract #4550

Influence of temporal resolution in determining pharmacokinetic parameters from CAIPIRINHA-Dixon-TWIST-VIBE DCE-MRI for breast lesions

Tianwen Xie^1,2, Yan Huang^1,2, Caixia Fu³, Grimm Robert⁴, Marcel Dominik Nickel⁴, Weijun Peng^1,2, and Yajia Gu^1,2

¹Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, ²Oncology, Shanghai Medical College, Fudan University, Shanghai, China, ³MR Applications Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Quantitative Imaging, Breast

Motivation: The quantitative parameters from dynamic contrast-enhanced (DCE) MRI can improve the diagnosis in characterizing breast cancer.

Goal(s): However, the influence of temporal resolution in determining pharmacokinetic parameters is still unclear.

Approach: In this study, we aimed to evaluate influence of scan temporal resolution on pharmacokinetic parameters and performance in diagnosing breast cancer.

Results: The results demonstrated that as temporal resolution decreases, K^trans, k_ep, and v_e increase, and there were no significant differences in AUCs in diagnosing breast cancer for any of the parameters.

Impact: This study transforms breast cancer diagnosis by validating the influence of temporal resolution in determining pharmacokinetic parameters. It encourages exploration into broader adaptations, aiming to provide the accurate pharmacokinetic quantitative parameters in the diagnosing cancer and assessing prognosis across multi-institutions.

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