Abstract #4553

Highly efficient simultaneous joint T1-T2 mapping for isotropic resolution 3D knee imaging at 0.55 T

Nicolás Garrido^1,2,3, Carlos Castillo-Passi^1,2,3, Nicole Araya², Andrew Phair³, Claudia Prieto^2,3,4, and René Botnar^1,2,3,4,5

¹Instituto de Ingeniería BIológica y Médica, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Millenium Institute for intelligent Healthcare Engineering, Santiago, Chile, ³School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ⁴Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁵Institute for Advanced Study, Technical University of Munich, Munich, Germany

Synopsis

Keywords: Quantitative Imaging, Low-Field MRI, Quantitative imaging

Motivation: Low-field 0.55T knee imaging promises to provide more accessible assessment of injuries. Anatomic imaging has been evaluated, however quantitative knee imaging at 0.55T has not been demonstrated.

Goal(s): To investigate the feasibility of 3D joint T1-T2 mapping for evaluation of the articular cartilage at 0.55T.

Approach: A free-running, 3D-radial sequence with golden-angle and spoiled gradient echo readout and 1mm³isotropic resolution was implemented using Pulseq for T1-T2 mapping. Bloch simulations were used for dictionary matching.

Results: The sequence was tested with a standardized phantom, showing good agreement with reference values, and promising results for in-vivo images in healthy subjects in a ~4min scan.

Impact: 3D joint T1-T2 mapping of knee articular cartilage with low-field MRI could provide a fast, more accessible and comprehensive test to assess knee injuries and chronic knee disease.

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