Abstract #4587

Quantitative MRI biomarker for classification of clinically significant prostate cancer: calibration for reproducibility across echo times

Karoline Kallis¹, Christopher C. Conlin², Courtney Ollison¹, Michael E. Hahn², Rebecca Rakow-Penner², Anders M. Dale^2,3,4, and Tyler M. Seibert^1,2,5

¹Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United States, ²Department of Radiology, University of California San Diego, La Jolla, CA, United States, ³Department of Neurosciences, University of California San Diego, La Jolla, CA, United States, ⁴Halicioglu Data Science Institute, University of California San Diego, La Jolla, CA, United States, ⁵Department of Bioengineering, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Prostate

Motivation: Restriction Spectrum Imaging restriction score (RSIrs) is a quantitative biomarker for detection of clinically significant prostate cancer. However, magnitude of RSIrs is influenced by imaging parameters, including echo time (TE).

Goal(s): We introduce a calibration technique to generate consistent RSIrs biomarker values for data acquired with different TEs.

Approach: We demonstrate a partial linear relationship between RSIrs and TE and compare calibrated to reference RSIrs values at two TEs

Results: The proposed calibration reduced bias between calibratedand reference RSIrs values.

Impact: Restriction Spectrum Imaging restriction score (RSIrs) is a quantitative MRI biomarker of clinically significant prostate cancer, but RSIrs values are dependent on echo time. This study introduces an approach to calibrate RSIrs for echo time variations and yield reproducible results.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.