Abstract #4588

Multi-contrast Multi-resolution UTE for Myelin Fraction Mapping

Nan Yin¹, Shuai Liu¹, Marco Reisert¹, Serhat Ilbey², Alexander Rau³, Uzay Emir^4,5, Michael Bock¹, and Ali Caglar Özen¹

¹Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²Bruker BioSpin, Karlsruhe, Germany, ³Deparment of Diagnostic and Interventional Radiology and Neuroradiology, University Medical Center Freiburg, Freiburg, Germany, ⁴Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ⁵School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Myelin, UTE, Bayesian

Motivation: The direct detection of myelin is not possible due to extremely short T2 of the myelin bilayer. Ultra-short T2* component can be calculated with ultra-short echo-time (UTE) sequences.

Goal(s): To evaluate the performance of the multi-contrast multi-resolution 3D-UTE sequence (mcUTE) in myelin fraction estimation.

Approach: Combining 1-1 binomial water-excitation pulses and zero-moment encoding in between, mcUTE enables simultaneous acquisition of quantitative and high-resolution water-excited structural images. Myelin fraction from mcUTE is compared to myelin water fraction method.

Results: Myelin fraction values were comparable with literature, and consistent within the subjects.

Impact: mcUTE can potentially be used as a single imaging modality for myelin fraction estimation since it produces both quantitative and a high resolution water-excited anatomical image data in 18mins with TE=20μs. Our results show the acquisition can be further accelerated.

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