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Abstract #4640

MR SIGNATURE MATCHING (MRSIGMA) WITH ADAPTIVE MOTION LEARNING FOR ROBUST REAL-TIME 4D MRI ON A 1.5T MR-LINAC

Syed Saad Siddiq1, Victor Murray1, Can Wu1, and Ricardo Otazo1,2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Keywords: Motion Correction, Radiotherapy

Motivation: Real-time 4D MRI on the MR-Linac is still sensitive to respiratory motion baseline drifts.

Goal(s): To further develop MRSIGMA for real-time adaptation to out-of-range anatomical changes during signature matching.

Approach: The motion dictionary was continuously updated using a sliding window of stack-of-stars data and fast motion-resolved Movienet reconstruction. MRSIGMA with adaptive motion learning was implemented in real-time using an external computer connected to the MR-Linac and tested on a programmable 4D phantom and a patient with pancreatic cancer.

Results: The adaptive motion learning approach was able to update the dictionary after 2 sliding window periods, which improved robustness of real-time volumetric motion tracking.

Impact: MRSIGMA with adaptive learning would enable real-time volumetric motion tracking robust to respiratory motion baseline drifts and other anatomical changes on the MR-Linac for improved monitoring and adaptation of radiotherapy of tumors affected by respiratory motion.

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Keywords