Keywords: Small Animals, Quantitative Imaging
Motivation: Intravoxel incoherent motion (IVIM) imaging can evaluate tissue microperfusion and diffusion information respectively, which can more accurately evaluate renal fibrosis (RF) in chronic kidney disease.
Goal(s): IVIM can reflect the occurrence and development of RF from two aspects of perfusion and diffusion respectively. It has a great application prospect for the evaluation of RF.
Approach: The dynamic changes of renal cortical and medullary signal with the progression of fibrosis were monitored by IVIM, and the compensatory effect of the contralateral kidney was analyzed.
Results: Some IVIM parameters of the renal cortex and medulla were moderately or strongly negatively correlated with RF.
Impact: Early detection and dynamic evaluation of the process of RF are crucial for reversing renal function damage. IVIM can reflect the development of RF from two aspects of perfusion and diffusion, which has a great application prospect for evaluating RF.
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