Abstract #4733

CEST imaging of ApoE –/– mouse brain during atherosclerosis development

Se Weon Park^1,2, Haoyun Su^1,2, and Kannie W.Y Chan^1,2,3,4,5

¹City University of Hong Kong, Hong Kong, Hong Kong, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, Hong Kong, ³Russell H. Morgan Department of Radiology and Radiological Science, , The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁵Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, Hong Kong

Synopsis

Keywords: Atherosclerosis, Atherosclerosis

Motivation: The molecular imaging and relationship between the brain and atherosclerosis are poorly understood.

Goal(s): To study the brain during atherosclerosis development and the association of atherosclerosis and brain using CEST MRI.

Approach: 3 months old ApoE –/– and C57BL/6 mouse brains were imaged using 3T preclinical MRI and CEST was applied, then three offsets, 3.5, –1.6 and –3.5 ppm, were extracted for post-processing.

Results: ApoE –/– mouse showed higher APT and rNOE signals than WT in thalamus, hippocampus and cortex, which are associated with neuroinflammation and cholesterol deposition during atherosclerosis development.

Impact: The underlying molecular changes of the brain during atherosclerosis development could enhance the identification of diseases at early stage using CEST MRI.

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