Abstract #4751

New Dual-Element 13C/1H Endorectal Coil for Improving mpMR-TRUS Guided Fusion Prostate Biopsies With Hyperpolarized C-13 Molecular Imaging

Daniel T Gebrezgiabhier^1,2, Lucas Carvajal³, Hsin-Yu Chen¹, Yaewon Kim⁴, Robert A Bok³, Matthew R Cooperberg⁵, Hao G Nguyen⁴, Katsuto Shinohara⁵, Kimberly Okamoto³, Mary Frost³, Zhen Wang³, Michael Ohliger³, Jeremy Gordon³, Peder Larson³, Rahul Aggarwal⁵, and Daniel Vigneron⁶

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, United Kingdom, ²Bioengineering, University of California, San Francisco, San Francisco, CA, United States, ³Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ⁴University of California, San Francisco, San Francisco, CA, United States, ⁵School of Medicine, University of California, San Francisco, San Francisco, CA, United States, ⁶Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States

Synopsis

Keywords: Prostate, Hyperpolarized MR (Non-Gas), TRUS guided biosy

Motivation: To address the issues with the original dual-element ¹³C/¹H endorectal coil (ERC).

Goal(s): We designed and fabricated a novel dual-element ¹³C/¹H ERC, validated with bench testing and then evaluated in 3T MRI studies.

Approach: Phantoms were imaged using the new ERC and the original ERC. Acquired data was then analyzed and respective SNR compared.

Results: The new ERC demonstrated substantially improved ¹³C and ¹H MRI sensitivity on bench electronic testing. In addition, the new ERC demonstrated substantial improvement in signal-to-noise ratio, and since the coil has successfully been used in hyperpolarized ¹³C-pyruvate, co-polarized ¹³C-urea+pyruvate multiparametric MRI patient studies for guiding prostate cancer biopsy.

Impact: Hyperpolarized ¹³C MRI, RF Coils, Metabolic imaging, Molecular imaging, Endorectal coil

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