Abstract #4768

Determining the Reproducibility and Reliability of 2D- and 4D flow MRI Mitral Valve Regurgitation Quantification Methods

Yasaman Safarkhanlo^1,2,3, Martina Boscolo Berto¹, Giancarlo Spano⁴, Jonathan Schütze¹, Anselm W. Stark⁴, Jessica AM Bastiaansen^3,5, and Christoph Gräni^1,3

¹Cardiology, Inselspital, University Hospital Bern, Bern, Switzerland, ²Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland, ³Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, ⁴Inselspital, University Hospital Bern, Bern, Switzerland, ⁵Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, University Hospital Bern, Bern, Switzerland

Synopsis

Keywords: Flow, Cardiovascular, Data Analysis, Challenges, Flow, Heart, Valves, Velocity & Flow, Validation, 4D-flow, 2D-flow

Motivation: Mitral valve regurgitation (MVR) quantification is crucial for diagnosis and treatment of patients with mitral valve disease. While different MRI based MVR quantification methods exist, their correlation with one another and their reproducibility and reliability remains unknown.

Goal(s): To determine the reproducibility and reliability of four different 2D- and 4D flow MVR volume quantification methods based on CMR.

Approach: The intermethod, inter- and intra-reader agreements between four different methods, 4D-flow_AIM,2D-PC_standard,2D-PC_MV, Volumetric, were compared for patients with severe secondary MVR.

Results: Among all techniques, 2D-PC_standard and Volumetric methods were the most reliable ones (ICC>0.99, P-value<0.001).

Impact: 2D-PCstandard and Volumetric methods quantify the MVR volume most consistently and further research with diverse MVR types and larger cohorts is needed to establish reliable conclusions for 2D-PCMV and 4D-flowAIM methods.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.