Abstract #4794

Impact of Oral Contrast Agents on Terminal Ileum Viscoelastic Properties Assessed by MR Enterography and MR Elastography

Rolf Reiter^1,2, Florian Nino Loch³, Britta Siegmund⁴, Anja Kühl⁵, Gero-Mathias Neumann⁶, Bernd Hamm¹, Jürgen Braun⁷, Ingolf Sack¹, and Sa-Ra Ro⁸

¹Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²BIH Charité Digital Clinician Scientist Program, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, Berlin, Germany, ³Surgery, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴Gastroenterology, Infectious Disease, Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁵iPATH.Berlin-Immunopathology for Experimental Models, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁶Internal Medicine, Gemeinschaftskrankenhaus Havelhöhe, Berlin, Germany, ⁷Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁸Radiology, Helios Klinikum Emil von Behring, Berlin, Germany

Synopsis

Keywords: Elastography, Elastography

Motivation: Although the feasibility of intestinal MR elastography has recently been demonstrated, the influence of bowel distension through oral contrast agents on gut viscoelastic properties remains elusive.

Goal(s): To investigate the influence of oral contrast agent-based bowel distension on the viscoelastic properties of the gut in healthy volunteers.

Approach: Healthy volunteers were scanned using MR enterography and MR elastography before and after the ingestion of 1000 ml of 2 % mannitol solution as oral contrast agent.

Results: Our results suggest that the bowel distension in MR enterography has no systematic impact on viscoelastic tissue properties of the terminal ileum.

Impact: This study suggests that bowel distension in MR enterography has no systematic impact on the assessment of viscoelastic tissue properties of the terminal ileum. Consequently, future studies investigating inflammatory bowel disease using intestinal MR elastography do not need to account for potential biases related to pre-stretched bowel walls after oral ingestion of contrast agents.

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