Abstract #4796

Evaluation of Spin-Echo EPI MR Elastography for Rapid Free-Breathing Quantification of Liver Stiffness

Sevgi Gokce Kafali^1,2, Bradley D. Bolster Jr.³, Timoteo I. Delgado^1,4, Shu-Fu Shih^1,2, Vibhas Deshpande⁵, Pedro Itriago Leon⁶, Kevin J. Johnson⁷, Maria Altbach^7,8, David S. Lu⁹, Steven-Huy B. Han¹⁰, Timothy R. Adamos¹¹, Shahnaz Ghahremani^1,11, Kara L. Calkins¹¹, and Holden H. Wu^1,2,4

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, ⁴Physics and Biology in Medicine Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, United States, ⁵US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Austin, TX, United States, ⁶US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Houston, TX, United States, ⁷Medical Imaging, The University of Arizona, Tucson, AZ, United States, ⁸Biomedical Engineering, The University of Arizona, Tucson, AZ, United States, ⁹Interventional Radiology, University of California, Los Angeles, Los Angeles, CA, United States, ¹⁰Transplant Hepatology, University of California, Los Angeles, Los Angeles, CA, United States, ¹¹Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Elastography, Pediatric, Liver Fibrosis

Motivation: Hepatic stiffness (HS), detected by MR elastography (MRE), is a biomarker for hepatic fibrosis. Liver MRE requires breath-holding (BH), which is challenging in children or people with liver disease. Spin-echo echo-planar-imaging (SE-EPI) MRE can quantify HS rapidly(~10 s), even with iron overload.

Goal(s): To evaluate free-breathing (FB) SE-EPI MRE without respiratory triggering or motion compensation in terms of agreement, repeatability, and measurable liver area [%] with respect to BH SE-EPI MRE.

Approach: BH and FB SE-EPI MRE were acquired in 23 children and 2 adults with liver biopsy.

Results: FB SE-EPI MRE provided fast, accurate, and repeatable HS with high measurable liver area.

Impact: The free-breathing (FB) MR elastography (MRE) of the liver based on spin-echo echo-planar-imaging (SE-EPI) produced accurate and repeatable hepatic stiffness with respect to standard breath-held SE-EPI MRE. FB SE-EPI MRE can be useful for populations who cannot hold their breath.

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