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Abstract #4883

A 36 month assessment of ASL reproducibility using a commercial perfusion phantom

Aaron Oliver-Taylor1, Shreya Nair2, Tom Hampshire1, Alessia Bianchi2, Olga Ciccarelli2, Marios Yiannakas2, and Xavier Golay1,3
1Gold Standard Phantoms Limited, Sheffield, United Kingdom, 2NMR Research Unit, UCL Queen Square Institute of Neurology, London, United Kingdom, 3Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom

Synopsis

Keywords: Phantoms, Phantoms, ASL, perfusion

Motivation: During longitudinal studies it is important to ensure quality assurance of MRI data. Here we use a commercially available perfusion phantom for QA of ASL in a 40-patient placebo-control study.

Goal(s): The goal of this study was to assess the utility of a perfusion phantom for QA of ASL MRI in a clinical trial setting.

Approach: Inversion recovery T1 measurements and pseudo-continuous ASL at 3 different phantom flow rates were scanned periodically on a 3T MRI system over a 36 month period.

Results: Once data due to errant phantom behaviour was discounted, the QA metric of labelling efficiency was in a reasonable range.

Impact: By acquiring independent T1 measures of the phantom’s perfusate, then computing ASL perfusion maps and comparing against the phantom’s pump flow rate, a useful QA metric can be established that can provide confidence in acquired subject ASL data.

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Keywords