Keywords: Flow, Cardiovascular
Motivation: Mitral valve regurgitation (MVR) is the most common heart valve diseases, but accurate quantification of MVR has been limited due to the dynamic motion of valves.
Goal(s): We hypothesize that volumetric flow information by 4D flow MRI with the compensation of MV motion could address this challenge.
Approach: MVR was measured using a simulated-in vitro model by comparing with actual flow from pump, ultrasound, and 4D flow MRI with/without a mitral registration algorithm.
Results: PISA method overestimated MVR. 4D flow MRI without algorithm seems to have similar the amount of actual MVR, while it decreased with employing algorithm.
Impact: Accurate quantification of regurgitation plays an important role for diagnosing patients with valvular diseases. This study would have a chance to measure accurate MVR quantification and quantify complex intracardiac blood flow using 4D flow MRI.
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