Abstract #4919

The relation between sleep indices and indices for brain interstitial fluid dynamics by MRI and the effects of orexin antagonists: a FLUID study.

Toshiaki Taoka^1,2, Kunihiro Iwamoto³, Seiko Miyata³, Ippei Okada³, Rintaro Ito^1,2, Rei Nakamichi², Toshiki Nakane², Kazushige Ichikawa⁴, Hirohito Kan⁵, Koji Kamagata⁶, Junko Kikuta⁶, Shigeki Aoki⁶, Akihiro Fujimoto⁷, Yuki Kogo⁷, Nobuyasu Ichinose^1,8, Shinji Naganawa², and Norio Ozaki⁹

¹Department of Innovative Biomedical Visualization (iBMV), Nagoya University, Nagoya, Japan, ²Department of Radiology, Nagoya University, Nagoya, Japan, ³Department of Psychiatry, Nagoya University, Nagoya, Japan, ⁴Department of Radiological Technology, Nagoya University, Nagoya, Japan, ⁵Department of Integrated Health Sciences, Nagoya University, Nagoya, Japan, ⁶Department of Radiology, Juntendo University of Medicine, Tokyo, Japan, ⁷Medical Headquarters, Eisai Co., Ltd., Tokyo, Japan, ⁸Department of CT-MR Solution Planning, Canon Medical Systems Corporation, Otawara, Japan, ⁹Pathophysiology of Mental Disorders Nagoya University Graduate School of Medicine, Nagoya University, Nagoya, Japan

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: The motivation is to investigate the relationship between sleep and interstitial fluid dynamics influenced by the administration of lemborexant, a dual orexin receptor antagonist.

Goal(s): The goal is to identify changes in indices of interstitial fluid dynamics related to sleep before and after the administration of lemborexant.

Approach: ALPS-index, Ktrans by DSC method, and choroid plexus volume were assessed as indicators of interstitial fluid dynamics.

Results: The sleep indexes on a night were found to correlate with the ALPS-index measured in the evening before that night's sleep. In multiple regression analysis, the ALPS-index was lower when sleep parameters were poor at baseline.

Impact: The sleep indexes on a night were found to correlate with the ALPS-index measured the evening before. The evaluation of the ALPS-index before and after lemborexant administration revealed that the baseline sleep status played a role in improving the index.

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