Abstract #4924

MR Elastography as a Potential Imaging Biomarker and Non-Invasive Method for Diagnosing Spontaneous Intracranial Hypotension

Ian Mark¹, Pragalv Karki², Jeremy Cutsforth-Gregory², Waleed Brinjikji², Ajay Madhavan², Steven Messina², Petrice Cogswell², John Chen², Richard Ehman², John Huston², and Matthew Murphy²

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Neurofluids, Elastography, SIH; CSF Leak

Motivation: Spontaneous intracranial hypotension (SIH) is a debilitating disease with a normal brain MRI in 20% of cases.

Goal(s): Our goal was to use MR elastography (MRE) to identify unique viscoelastic patterns in SIH patients.

Approach: We performed brain MRE in 15 SIH patients and compared their mechanical properties to 65 healthy controls.

Results: SIH patients exhibited significant differences in both stiffness and damping ratio compared to healthy controls.

Impact: We demonstrate MRE as a potential imaging biomarker and a non-invasive method for diagnosing SIH, including patients with a normal brain MRI.

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