Keywords: Normal Development, Neonatal
Motivation: Despite white matter perivascular spaces visual grades in preterm was not different from term infants, whether the glymphatic system function differently with preterm and term infants remains unclear.
Goal(s): Exploring development of glymphatic system function in very preterm (VP) infants, comparing with term infants.
Approach: The diffusion along perivascular space index (ALPS) was used to evaluate the glymphatic system function via diffusion tensor images (DTI).
Results: The DTI-ALPS index was significantly lower in VP neonates than VP infants at term equivalent age (TEA) or term neonates. However, the DTI-ALPS index in VP infants at TEA was not found differences with term neonates.
Impact: The glymphatic system function was developing with gestational age, while very preterm infants presented “catch-up” growth pattern up to TEA.
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