Abstract #4967

Modulation of cross-hierarchy propagating waves across sleep stages

Xufu Liu¹, Dante Picchioni², Yifan Yang¹, Jacco de Zwart², Jeff Duyn², and Xiao Liu^1,3

¹Department of Biomedical Engineering, The Pennsylvania State University, University Park, State College, PA, United States, ²National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ³Institute for Computational and Data Sciences, The Pennsylvania State University, University Park, State College, PA, United States

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), sleep

Motivation: Endogenous brain activity plays a pivotal role during sleep. Previous research suggested that endogenous brain activity during wakefulness can take the form of infra-slow waves propagating along the cortical hierarchical gradient. But it remains unclear how these infra-slow waves modulate across sleep stages.

Goal(s): To elucidate sleep stage dependent changes in the cross-hierarchy propagations.

Approach: We measured and analyzed overnight fMRI/EEG data.

Results: The cross-hierarchy propagating waves modulate systematically across sleep stages. REM sleep features more frequent propagations from sensory/motor regions to higher-order brain networks, which are associated with eye movements and characterized by phase shifts in the thalamus, pons, and visual cortex.

Impact: The findings reveal a highly structured nature of endogenous brain dynamics during REM sleep and their potential link to known REM features of electrophysiological PGO waves and eye movements.

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