Keywords: Gray Matter, Brain, Mendelian randomization; sleep;hippocampus
Motivation: The causal relationship between the sleep-related traits and the plasticity of subcortical brain volumes remains unclear.
Goal(s): This study aims to explore the causal relationship between two sleep-related traits (i.e., sleep duration and insomnia) and subcortical volumes.
Approach: Two-sample Mendelian randomization (MR) analysis
Results: We found a significant causal effect of insomnia but not sleep duration on the hippocampal volume. Moreover, insomnia showed significant causal influence on the structural plasticity of the hippocampus, which may associated with the rates of hippocampal atrophy.
Impact: The causal effect of insomnia on the hippocampal volume and plasticity may explain the adverse effect of insomnia on memory and may offer new evidence which could push the exploration of sleep management to delay the course of neurodegenerative diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords