Keywords: Pulse Sequence Design, Atherosclerosis, 3D DWI
Motivation: Non-Cartesian sampling offers advantages in motion robustness and speed, crucial in 3D DWI.
Goal(s): We aimed to improve 3D DWI using RAZER trajectory to improve the 3D DWI imaging with reducing scan time while preserving imaging quality.
Approach: We implemented 3D DW RAZER sequence with integrated radial and EPI sampling and conducted 3D DWI studies in a phantom and human carotid arteries.
Results: The RAZER DWI sequence offered a clearer depiction of the carotid arterial structure and reliable ADC measurements without geometric distortion when compared to 2D ss-DW EPI, all within a scan time of less than two minutes.
Impact: This study introduces a motion-robust 3D DWI with faster imaging capabilities, potentially improving vulnerable plaque identification. It addresses conventional DWI limitations, providing a valuable resource for the detection of possible events and improved patient outcomes in ischemic stroke.
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