Abstract #5021

Increased Intracortical T1w/T2w Ratio in Patients with Chronic Schizophrenia

Gayatri Maria Schur^1,2,3,4, Ruoyu Luie Wang^2,3,5, Ryn Flaherty^2,3,4, Yu Veronica Sui^2,3,4, and Mariana Lazar^2,3

¹Medical Scientist Training Program, New York University. Grossman School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ⁴Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁵SUNY Downstate Health Sciences University, New York, NY, United States

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Schizophrenia

Motivation: While dysmyelination is known to occur in white matter in schizophrenia, studies characterizing intracortical myelin in vivo are limited.

Goal(s): Our goal was to quantify intracortical myelin in chronic schizophrenia (SZ) vs. healthy controls (HC), and to correlate myelination with volumetric changes.

Approach: We used T1w/T2w ratio to map cortical myelin.

Results: We found decreased cortical volume but increased T1w/T2w ratio in frontal and temporal regions in SZ vs. HC. Apart from potentially increased ectopic myelin content, increased T1w/T2w in patients may also reflect iron deposition or presence of glial cells which contain high intracellular iron.

Impact: Characterizing intracortical myelin will help refine the dysmyelination hypothesis of schizophrenia. Our results in a chronic schizophrenia group support this hypothesis and further suggest potential abnormalities in cortical iron and glial cells.

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