Abstract #5041

Evaluation of the change in magnetic susceptibility values of knee joint cartilage in patients with osteoarthritis using UTE-QSM

Jing Li¹, Shaoxin Xiang², Xianqi Wang³, Xiaohong Tian¹, Bing Ji¹, Shanshan Hu¹, Ming Zhang⁴, Yu Xin Yang², Hongjiang Wei^4,5, and Wei Chen³

¹Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China, Chongqing, China, ²MR Collaboration, United Imaging Research Institute of Intelligent Imaging, Beijing, China, Beijing, China, ³7T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China, Chongqing, China, ⁴School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China, ⁵The National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai, China., Shanghai, China

Synopsis

Keywords: Cartilage, Joints, UTE-QSM

Motivation: Quantitative susceptibility mapping (QSM) may be a useful tool for studying the characteristics of collagen fibers in knee cartilage.The susceptibility quantification using GRE with fat saturation and relatively long TE may be further improved using UTE-QSM.

Goal(s): To measure the change in susceptibility values of knee cartilage in patients with different grades of OA using UTE-QSM.

Approach: A total of 13 knees from 10 patients who underwent both X-ray and MRI-UTE were enrolled.

Results: Our results show that in the posterior regions of the medial femoral condyle and lateral femoral condyle, the magnetic susceptibility value significantly decreases with the increase of OA grade.

Impact: UTE-QSM can promote osteoarthrologists and radiologists to better understand knee OA from different dimensions, and can provide more imaging evidence for monitoring the progress of OA, formulating treatment plans, and evaluating treatment effects.

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