Abstract #5057

Ultrashort Echo Time MRI for Pediatric Patients with Craniofacial Abnormalities

Nada Kamona^1,2, Jinggang J. Ng³, Yohan Kim³, Brian-Tinh D. Vu^1,2, Brandon C. Jones^1,2, Hyunyeol Lee⁴, Holly Corday³, Connor Wagner³, Hee Kwon Song¹, Sandhya Konar¹, Chamith S. Rajapakse^1,5, Scott P. Bartlett³, and Felix W. Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Division of Plastic, Reconstructive, and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ⁴School of Electronics Engineering, Kyungpook National University, Daegu, Korea, Republic of, ⁵Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: MSK, Bone

Motivation: Ionizing radiation risk from CT remains a concern for pediatric patients with craniofacial abnormalities.

Goal(s): Use high-resolution bone-selective MRI for cranial bone imaging and evaluate feasibility in pediatric patients.

Approach: We quantitatively assessed a new echo-subtraction UTE sequence against clinical CT and another well-known MRI technique to assess their strengths and limitations.

Results: The proposed UTE sequence had high agreement with CT among the 3D rendered bone segmentations in terms of Dice similarity coefficient and quantification of clinical craniometric measurements. Furthermore, the bone-selective MR images clearly depict thin bone structures with attenuation of both soft-tissues and air.

Impact: Craniofacial imaging with the proposed ultrashort echo time sequence has high agreement with CT in pediatric patients. MRI can be a reliable non-ionizing and radiation-free modality for pediatric patients who are at increased risk of radiation malignancy.

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