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Abstract #5061

Total tumor apparent diffusion coefficient histogram parameters identify ISS stages in multiple myeloma with diffuse infiltration

Jiao Li1, Qin Wang1, Junde Zhou1, Dong Liu1, Jinxia Zhu2, Robert Grimm3, Huadan Xue1, and Zhengyu Jin1
1Peking Union Medical College Hospital, beijing, China, 2MR Collaboration, Siemens Healthineers Ltd, beijing, China, 3MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Diffusion Analysis & Visualization, Hematologic, multiple myeloma, whole-body diffusion-weighted imaging

Motivation: Is there any difference in the ttADC histogram parameters at different ISS stages in multiple myeloma patients with diffuse infiltration visually?

Goal(s): The goal was to explore the difference in ttADC histogram parameters and clinical indicators in multiple myeloma patients with diffuse infiltration at different ISS stages.

Approach: The ttADC histogram parameters were obtained by sketching the lesions of the whole body on WB-DWI images using MRTTL software.

Results: Age, hemoglobin, creatinine, and ttADC_5% were different at different ISS stages.

Impact: Diffuse infiltration is generally thought to be associated with a poorer prognosis for MM patients. Our study shows that although all patients have diffuse infiltration, different ttADC histogram parameters may result in different prognosis.

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Keywords