Keywords: DWI/DTI/DKI, Tumor, cervical cancer; radiotherapy;diffusion-weighted imaging;apparent diffusion coeffificient
Motivation: Radiotherapy (RT) is regarded as standard therapy for locally advanced cervical cancer. To date there are no accepted modalities that can reliably predict treatment response.
Goal(s): Present study aimed to explore the baseline and interim-ADC as well as change in ADC for predicting treatment outcomes.
Approach: 80 patients underwent pelvis MRI at least three times: before treatment, juring the course of RT and after completion of RT. Following values were calculated: Pre-ADC , Interim-ADC, △ADC and △%ADC. Treatment outcome was assessed by RECIST.
Results: Pre-treatment tumor size and interim-ADC could be potential biomarkers for predicting treatment outcomes in cervical cancer patients referred for RT.
Impact: The results of present study can evaluate the early efficacy of RT, in order to allow for the timely adjustment of treatment plans, improve the efficacy and prognosis, and provide a reference for the clinical individualized treatment of cervical cancer.
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