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Abstract #5068

Associations between time-dependent diffusion MRI parameters and WHO/ISUP grade of clear cell renal cell carcinoma

Chunlei He1, Yuntian Chen1, Xiaoxiao Zhang2, and Bin Song1
1Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Clinical, Philips Healthcare, China, Chengdu, China

Synopsis

Keywords: Microstructure, Kidney

Motivation: OGSE-MRI provides more information on kidney cancer prognosis, metastasis possibility, specific survival rate in the future.

Goal(s): To explore whether parameters derived from OGSE can demonstrate microstructure in clear cell renal cell carcinoma

Approach: Patients suspected of ccRCC who underwent diffusion-weighted imaging were employed to quantify the time-dependent diffusion MRI-based microstructural parameters cell diameter (D), intracellular volume fraction (vin), cellularity, and diffusivities (Dex).

Results: ccRCC with high WHO/ISUP grade show higher cellularity and vin, while lower D and Dex parameters.

Impact: The OGSE MRI parameters correlates with pathologic grades and demonstrates promise for characterizing renal carcinoma.

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Keywords