Abstract #5074

Microstructural Abnormalities of Grey Matter and White Matter in Children with Basic-type Intermittent Exotropia using NODDI Technology

Huixin Li¹, Qinglei Shi², Jie Hong¹, Jie Hao¹, Zhengyong Chen³, Mengdi Zhou⁴, Haoran Zhang³, Xianchang Zhang⁵, Xiang Wan⁶, Zhaohui Wan⁴, and Jing Fu¹

¹Beijing Tongren Hospital, Beijing Eye Center, Beijing, China, ²Chinese University of Hong Kong (Shenzhen) School of Medicine, Shenzhen Research Institute of Big Data, Hong Kong, China, ³Chinese University of Hong Kong (Shenzhen) School of Data Science, Hong Kong, China, ⁴Department of Radiology, Beijing Tongren Hospital, Beijing, China, ⁵MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China, ⁶Shenzhen Research Institute of Big Data, Hong Kong, China

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniques, NODDI; intermittent exotropia; microstructural changes; TBSS; binocular function

Motivation: Intermittent exotropia (IXT) is quite common in children. The exact pathogenesis is not clear, which makes it difficult to make early diagnosis and evaluate progression.

Goal(s): To investigate the microstructural changes in vivo in children with IXT and explore the potential neuropathological mechanisms.

Approach: 31 IXT children and 37 controls were enrolled. Brain gray matter (GM) and the white matter (WM) regions extracted from their whole-brain MRI data were compared using the NODDI technology and TBSS method.

Results: Microstructural changes in GM and WM between the two groups were found, located in the visual perception and oculomotor control associated areas.

Impact: The parameters derived from NODDI can demonstrate the microstructural abnormalities in primary, advanced visual center and oculomotor center pathway, which maybe a potential tool in diagnosis and evaluation the IXT patients.

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