Keywords: Deuterium, Spectroscopy
Motivation: Deuterium metabolic imaging (DMI) is used to study metabolic processes, but the effect of varying substrate doses on DMI data in the brain is not yet known
Goal(s): Comparing different doses aims to reduce cost, while still achieving sufficient sensitivity for DMI
Approach: Three healthy participants received different doses of [6,6'-2H2]glucose on two occasions and underwent dynamic 7T DMI scans
Results: In 120-minutes after ingesting [6,6'-2H2]glucose , there is no clear difference in the signal of 2H-glucose/2H-Glx in the brain between the 0. 50-0.75g/kg doses. However, there was an earlier decrease in the signal when using the 0.25g/kg dose in one subject.
Impact: We compared three different doses [6,6'-2H2]glucose for Deuterium Metabolic Imaging of the brain, at 7T. Metabolite signals were comparable for the 0.50g/kg and 0.75g/kg doses, making 0.50g/kg a potential cost-saving alternative for clinical translation.
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