Abstract #5081

31P MRSI in Pediatric Low Grade Gliomas During Treatment at 7T

Philipp Lazen^1,2, Karleen T. Oonk³, Iris V. Obdeijn⁴, Dennis W. J. Klomp³, Sabine L. A. Plasschaert⁴, Maarten H. Lequin^3,4, Giorgo L. Porro⁵, Gilbert Hangel^1,2, Evita C. Wiegers³, and Jannie P. Wijnen³

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands, ⁵Department of Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Non-Proton, Pediatric, Brain tumor, 7T, Neuro, 31P

Motivation: Treatment monitoring in pediatric brain tumors is often challenging. Non-invasive tools are needed to assess tumor activity accurately.

Goal(s): To monitor changes in phospholipid metabolism (i.e., phosphomonoesters/phosphodiesters [PME/PDE]) in pediatric low grade gliomas.

Approach: Eleven pediatric brain tumor patients underwent 31P-MRSI at 7T. PME/PDE in the tumor was compared to a normal-appearing brain voxel. Clinical outcomes were assessed, and results were compared between treatment and wait-and-scan groups.

Results: Tumors selected for treatment showed higher PME/PDE ratios at baseline, hinting at potential aggressiveness. These ratios decreased during treatment but remained stable in the wait-and-scan group.

Impact: Treatment monitoring in pediatric brain tumors is often challenging. Using 31P-MRSI we showed that tumors selected for treatment exhibited higher PME/PDE, signifying potential tumor aggressiveness. PME/PDE levels decreased during treatment, indicating potential for non-invasive assessment of treatment effects.

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