Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Hyperpolarized (HP) 129Xe magnetic resonance (MR) spectroscopy provides useful biomarkers of gas exchange. Some groups analyze phased spectra in the frequency domain, while others employ time-domain fitting. However, these two approaches have never been compared to determine the reliability of the metrics resulting from each approach.
Goal(s): This study compares the feasibility, sensitivity, and repeatability of these two methodologies.
Approach: 129Xe MRS acquired at 3 Tesla from 242 scans–include 55 repeated measurements of 110 scans–was evaluated using both methods.
Results: Time-domain fitting was applicable to all scans, yielded more physiologically plausible chemical shifts and were more repeatable.
Impact: Fitting 129Xe spectra acquired at 3 Tesla in the temporal domain outperforms phase correcting and fitting spectra in the frequency domain.
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