Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Hyperpolarized 129Xe gas exchange magnetic resonance spectroscopy (MRS) lacks standardized healthy reference values.
Goal(s): To standardize 129Xe gas exchange MRS biomarker reference values across different MRI systems and estimate a T2* for consistent analysis of 129Xe gas exchange MRI.
Approach: Healthy 18-30 yr old non-smokers underwent 129Xe MRS using the consortium recommended protocol across three research centers and three different MRI vendors.
Results: Findings indicated consistent RBC-to-membrane ratios across sites but slight differences in RBC shifts, oscillation amplitudes, and T2* values.
Impact: Establishing healthy reference values for multi-site 129Xe spectroscopy will facilitate its incorporation into collaborative respiratory research.
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