Abstract #5095

Evaluation of kidney injury using ASL and BOLD MRI: an experimental study in rats with CCl4-induced liver cirrhosis

Jiaming Qin¹, Shuangshuang Xie², Yongquan Yu³, Yumeng Zhao⁴, Jiaqi Yang⁵, Caixin Qiu⁶, Xiaotian Li⁷, Cheng Zhang⁵, Zhandong Hu⁶, Jinxia Zhu⁸, Bernd Kuehn⁹, and Wen Shen⁶

¹The School of Medicine, Nankai Univeisity, Tianjin, China, ²Department of Radiology, Tianjin First Central Hospital, Tianjin, China, ³Weihai Central Hospital, Weihai, China, ⁴Department of Radiology, Nankai Univeisity, Tianjin, China, ⁵Tianjin Medical University, Tianjin, China, ⁶Tianjin First Central Hospital, Tianjin, China, ⁷Nankai Univeisity, Tianjin, China, ⁸Siemens Healthineers, Beijing, China, ⁹Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: fMRI Analysis, Animals

Motivation: Noninvasive and sensitive methods for assessing chronic liver disease-associated kidney injury are needed in clinics.

Goal(s): We investigated the potential of arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) MRI for diagnosing and evaluating chronic liver disease-associated kidney injury progression.

Approach: We observed the renal blood flow (RBF) and T2* changes in rats with CCl₄-induced chronic liver disease and compared imaging, pathological, and biochemical indicators at different time points.

Results: During chronic liver disease development in rats, RBF and T2* gradually decreased, and ASL and BOLD MRI were more sensitive than serum creatinine in diagnosing renal injury.

Impact: Compared with serum creatinine, ASL and BOLD MRI exhibited more sensitive diagnostic value for liver cirrhosis-associated renal injury, providing a noninvasive and reliable method for monitoring kidney injury in patients with chronic liver disease.

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