Keywords: Tumors (Pre-Treatment), Neuro, diffuse midline glioma; H3K27M altered; whole-brain tumor burden; cortical myelin content; cortical thickness;
Motivation: Diffuse midline glioma (DMG) represents a systemic disease due to its ability to disseminate tumor cells throughout the whole brain. Current imaging techniques, however, provide information only about the main tumor and its immediate surroundings.
Goal(s): We employed comprehensive cortical mapping to gain insights into the individual tumor burden across whole-brain using structural MRI.
Approach: Cortical thickness and myelin content was calculated from participants using Human Connectome Project pipeline.
Results: DMG has the capacity to induce cortical thickness compensation while concurrently leading to cortical demyelination in numerous non-lesional regions. Notably, DMG harboring H3K27M altered exhibited specific cortical myelin and thickness reorganization patterns.
Impact: These findings may open up the possibility of tailoring treatment strategies to the individual disease severity and distribution within the patient's brain, potentially enhancing the effectiveness of both current and future treatment approaches.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords